Article
Molecular patterns identify distinct subclasses of myeloid neoplasia.
Nature communications - 30 May 2023
Kewan Tariq, Durmaz Arda, Bahaj Waled, Gurnari Carmelo, Terkawi Laila, Awada Hussein, Ogbue Olisaemeka D, Ahmed Ramsha, Pagliuca Simona, Awada Hassan, Kubota Yasuo, Mori Minako, Ponvilawan Ben, Al-Share Bayan, Patel Bhumika J, Carraway Hetty E, Scott Jacob, Balasubramanian Suresh K, Bat Taha, Madanat Yazan, Sekeres Mikkael A, Haferlach Torsten, Visconte Valeria, Maciejewski Jaroslaw P
Abstract excerpt
Genomic mutations drive the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia. While morphological and clinical features have dominated the classical criteria for diagnosis and classification, incorporation of molecular data can illuminate functional pathobiology. Here we show that unsupervised machine learning can identify functional objective molecular clusters, irrespective of anamnestic...
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