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Article

Prognostic score including gene mutations in chronic myelomonocytic leukemia.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jul 2013

Itzykson Raphaël, Kosmider Olivier, Renneville Aline, Gelsi-Boyer Véronique, Meggendorfer Manja, Morabito Margot, Berthon Céline, Adès Lionel, Fenaux Pierre, Beyne-Rauzy Odile, Vey Norbert, Braun Thorsten, Haferlach Torsten, Dreyfus François, Cross Nicholas C P, Preudhomme Claude, Bernard Olivier A, Fontenay Michaela, Vainchenker William, Schnittger Susanne, Birnbaum Daniel, Droin Nathalie, Solary Eric

Abstract excerpt

PURPOSE: Several prognostic scoring systems have been proposed for chronic myelomonocytic leukemia (CMML), a disease in which some gene mutations-including ASXL1-have been associated with poor prognosis in univariable analyses. We developed and validated a prognostic score for overall survival (OS) based on mutational status and standard clinical variables. PATIENTS AND METHODS: We genotyped ASXL1 and up to 18...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myelomonocytic, Chronic

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Source

Identifiers

PMID: 23690417
DOI: 10.1200/JCO.2012.47.3314

Genes

ASXL1
CBL
IDH2
SRSF2
FLT3
IDH1
JAK2
KRAS
NPM1
NRAS
RUNX1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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