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Mutational architecture defines disease behaviour in an Indian cohort of Myeloproliferative Neoplasms: Foundations for a Genomics-first classification.

Leukemia research - 1 Jun 2026

Singh Suvir, Jain Kunal, Dhillon Barjinderjit, Narang Vikram, Pandita Renu Moti, Singh Jagdeep, Grewal Gurvinder Singh

Abstract excerpt

AIMS: Data on BCR::ABL1-negative MPN genomics in India are limited. We aimed to define mutational architecture and evaluate co-mutation burden for risk stratification. METHODS: We analysed 179 patients (median age 57 years; 36.3% ≤50 years). Targeted NGS covering relevant myeloid genes was performed in 104 patients (58%). Prognostic factors and latent molecular subgroups were evaluated using Cox proportional...

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Identifiers

PMID: 41926860
DOI: 10.1016/j.leukres.2026.108215

Genes

TET2
ABL1
ASXL1
BCR
JAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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