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Article

Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer.

Oncogene - 1 Sept 2020

Roh Jae-Il, Lee Jaehoon, Sung Young-Hoon, Oh Jahyun, Hyeon Do Young, Kim Yujin, Lee Seungeon, Devkota Sushil, Kim Hye Jeong, Park Bomin, Nam Taewook, Song Yaechan, Kim Yonghwan, Hwang Daehee, Lee Han-Woong

Abstract excerpt

KRAS-mutant non-small cell lung cancer (NSCLC) is a major lung cancer subtype that leads to many cancer-related deaths worldwide. Although numerous studies on KRAS-mutant type NSCLC have been conducted, new oncogenic or tumor suppressive genes need to be detected because a large proportion of NSCLC patients does not respond to currently used therapeutics. Here, we show the tumor-promoting function of a cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32728173
DOI: 10.1038/s41388-020-01399-5
PMCID: PMC7471098

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