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Article

Immune phenotype and RAS/BRAF status predict outcomes after lung metastasectomy for colorectal cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Oct 2026

Martin-Cullell Berta, Piedra Aida, Virgili Anna Cristina, Fumagalli Caterina, Cerdà Paula, Mirallas Oriol, Sanz Judit, Restrepo Sara, Trujillo Juan Carlos, Martínez Elisabeth, Belda-Sanchís Jose, Szafranska Justyna, Páez David

Abstract excerpt

PURPOSE: Colorectal cancer (CRC) presents a marked biological heterogeneity, and the lung is a frequent site of metastatic spread. Although pulmonary metastasectomy can lead to a long-term survival, recurrence rates remain high and prognostic markers are lacking. This study evaluated the prognostic value of clinical, molecular, and histopathological features in CRC patients undergoing lung metastasectomy....

Read the complete abstract on PubMed

Topics

Humans
Colorectal Neoplasms
Proto-Oncogene Proteins B-raf
Lung Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Retrospective Studies

Female

Metastasectomy

Male

Prognosis

Aged

Phenotype

Middle Aged

Mutation

ras Proteins

Neoplasm Recurrence, Local

Biomarkers, Tumor

Adult

Source

Identifiers

PMID: 41963636
DOI: 10.1007/s12094-026-04344-2

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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