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Prognostic impact of spread through air spaces and its association with KRAS mutation and histopathologic factors in resected colorectal lung metastases.

Polish journal of pathology : official journal of the Polish Society of Pathologists - 8 Jun 2026

Geçmen Gonca Gül, Hallaç Keser Sevinç, Ece Dilek, Çoban Kökten Şermin, Çimenoğlu Berk, Güler Ayşen, Pala Arif, Sensu Sibel

Abstract excerpt

Spread through air spaces (STAS) represents an independent prognostic factor for poor overall survival (OS) in patients with colorectal carcinoma who underwent pulmonary metastasectomy. This study aims to evaluate the prognostic impact of STAS and explore its associations with histopathologic features and KRAS mutation status/subtypes.We retrospectively analyzed 61 consecutive patients with colorectal cancer...

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PMID: 42458968
DOI: 10.5114/pjp.2026.161535

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