Article
Causal association between serum total bilirubin and cholelithiasis: a bidirectional two-sample Mendelian randomization study.
Frontiers in endocrinology - 1 Jan 2023
Sun Yang, Yang Shaojie, Dai Wanlin, Zheng Zhuyuan, Zhang Xiaolin, Zheng Yuting, Wang Jingnan, Bi Shiyuan, Duan Yunlong, Wu Shuodong, Kong Jing
Abstract excerpt
Background: Observational studies about the association between serum total bilirubin and cholelithiasis are inconsistent. Hence, it is essential to reevaluate the association between serum total bilirubin and cholelithiasis and to verify whether such association is causal or not. Methods: We selected single-nucleotide polymorphisms (SNPs) that are strongly associated with exposure as instrumental variable and...
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