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Article

The Contributions of Multiple Polygenic Scores in Predicting Liability for Major Depressive Disorder and Its Comorbidity with Alcohol Use Disorder.

Behavior genetics - 1 Mar 2026

Wells Jonathan L, Rabinowitz Jill A, Maher Brion S, Gentry Amanda E, Burch James B, Prom-Wormley Elizabeth C

Abstract excerpt

The inclusion of polygenic scores (PGS) from genetically correlated traits such as Major Depressive Disorder (MDD) and alcohol use disorder (AUD) may improve the prediction of these outcomes and their comorbidity. Despite the importance of this work, few studies have evaluated the efficacy of this possibility. The current study evaluates the use of MDD and AUD PGS individually and together to improve the...

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Identifiers

PMID: 41961466
DOI: 10.1007/s10519-026-10263-3
PMCID: PMC13132973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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