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Article

StarD5 Regulates Cholesterol Homeostasis to Promote Colorectal Cancer Progression and the Cancer Stem Cell Phenotype.

Molecular cancer research : MCR - 4 Aug 2026

Sharon Chetna, Rodriguez-Agudo Daniel, Boothello Rio S, Haneefa Shoja M, Pandak William M, Gil Gregorio, Patel Bhaumik B

Abstract excerpt

An aberration in cellular, especially plasma membrane (PM), cholesterol level is arguably the most critical targetable hallmark of colorectal cancer and colorectal cancer stem cell (CRCSC) phenotypes. We recently identified Star-related lipid transfer protein 5 (StarD5) as an intracellular cholesterol transport protein that regulates PM cholesterol levels. In this study, we show that StarD5 protein levels are...

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Identifiers

PMID: 41954600
DOI: 10.1158/1541-7786.MCR-23-1084
PMCID: PMC13234776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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