Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Physical and genetic associations of the Irc20 ubiquitin ligase with Cdc48 and SUMO.

PloS one - 1 Jan 2013

Richardson Aaron, Gardner Richard G, Prelich Gregory

Abstract excerpt

A considerable percentage of the genome is dedicated to the ubiquitin-proteasome system, with the yeast genome predicted to encode approximately 100 ubiquitin ligases (or E3s), and the human genome predicted to encode more than 600 E3s. The most abundant class of E3s consists of RING finger-containing proteins. Although many insights have been obtained regarding the structure and catalytic mechanism of the E3s,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Cell Cycle Proteins
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutant Proteins

Share to Small Ubiquitin-Related Modifier Proteins

Share to Sumoylation

Share to Ubiquitin-Protein Ligases

Share to Valosin Containing Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 24155900
DOI: 10.1371/journal.pone.0076424
PMCID: PMC3796546

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Physical and genetic associations of the Irc20 ubiquitin ligase with Cdc48 and SUMO.PMID 24155900Read ↗

CRL4s: the CUL4-RING E3 ubiquitin ligases.Semantic proximity Read ↗

Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.Semantic proximity Read ↗

A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.Semantic proximity Read ↗

CRL Ubiquitin Ligases and DNA Damage ResponseSemantic proximity Read ↗

The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.Semantic proximity Read ↗

The NEF4 complex regulates Rad4 levels and utilizes Snf2/Swi2-related ATPase activity for nucleotide excision repair.Semantic proximity Read ↗

The ubiquitin-selective chaperone Cdc48/p97 associates with Ubx3 to modulate monoubiquitylation of histone H2B.Semantic proximity Read ↗

Structural basis for ubiquitin recognition by ubiquitin-binding zinc finger of FAAP20.Semantic proximity Read ↗

Cdc48: A Swiss Army Knife of Cell BiologySemantic proximity Read ↗

Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Ligase-dependent and independent functions of the C-terminus of Mms21 contribute to optimal growth and genome stability in Saccharomyces cerevisiae.Semantic proximity Read ↗

The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase familySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.