Article
Molecular cloning and functional characterization of UBC13 and MMS2 from Candida albicans.
Gene - 30 Mar 2022
Zeng Chuanwen, Xiao Wei
Abstract excerpt
To maintain genome stability, eukaryotes have evolved a powerful DNA damage response system called DNA-damage tolerance (DDT) to deal with replication-blocking lesions. In the budding yeast Saccharomyces cerevisiae, K63-linked polyubiquitination of proliferating cell nuclear antigen (PCNA) is mediated by a Ubc13-Mms2 heterodimer, leading to error-free DDT. Candida albicans is one of the most studied fungal...
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