CYP2C:TG haplotype in Ecuador and Nicaragua: insights into CYP2C19 genotype-phenotype correlation in context to Mestizo populations.

doi:10.1080/14622416.2026.2646516

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CYP2C:TG haplotype in Ecuador and Nicaragua: insights into CYP2C19 genotype-phenotype correlation in context to Mestizo populations.

Pharmacogenomics - 1 Jan 2026

de la Cruz Carla González, Altamirano-Tinoco Catalina, Villatoro-García Juan Antonio, Mata-Martín Carmen, Peñas-Lledó Eva M, Ramírez-Roa Ronald, Terán Enrique, Llerena Adrián

Abstract excerpt

AIM: The impact of the CYP2C:TG haplotype on CYP2C19-mediated omeprazole metabolism was evaluated. PATIENTS AND METHODS: CYP2C19 enzymatic activity was assessed in 234 volunteers from Nicaragua and Ecuador using the omeprazole/5-hydroxyomeprazole metabolic ratio within a validated CEIBA cocktail protocol. Genotyping included CYP2C19 alleles (*2, *3, *4, *5, *17) and CYP2C:TG defining CYP2C18 variants (rs2860840,...

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Identifiers

PMID: 41949056
DOI: 10.1080/14622416.2026.2646516
PMCID: PMC13078237

Genes

CYP2C19
TG
CYP2C18

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