Multi-ethnic distribution of clinically relevant CYP2C genotypes and haplotypes.

Abstract excerpt

To determine CYP2C19 and CYP2C8 allele frequencies, 28 coding and/or functional variants were genotyped in 1250 African-American, Asian, Caucasian, Hispanic and Ashkenazi Jewish (AJ) individuals. The combined CYP2C19 variant allele frequencies ranged from ∼0.30 to 0.41; however, the CYP2C8 frequencies were much lower (∼0.04-0.13). After incorporating previously reported CYP2C9 genotyping results from these...

Topics

Join the communities discussing this publication.

• Aryl Hydrocarbon Hydroxylases
• Asian People
• Black or African American
• Black People
• Cytochrome P-450 CYP2C19