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Article

Relationships between CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 metabolic phenotypes and genotypes in a Nicaraguan Mestizo population.

The pharmacogenomics journal - 1 Apr 2021

de Andrés Fernando, Altamirano-Tinoco Catalina, Ramírez-Roa Ronald, Montes-Mondragón Carlos F, Dorado Pedro, Peñas-Lledó Eva M, LLerena Adrián

Abstract excerpt

Interethnic variability in the drug-metabolizing capacity of CYP450 enzymes may lead to discrepancies in the relationship between genotypes and phenotypes worldwide. The present study was aimed to analyze for the first time whether there is a relationship between clinically relevant CYP450 genetic polymorphisms and their drug oxidation capacity (metabolic phenotype) in a population of healthy Nicaraguan...

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PMID: 33024249
DOI: 10.1038/s41397-020-00190-9

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