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Article

Impact of CYP2C:TG Haplotype on CYP2C19 Substrates Clearance In Vivo, Protein Content, and In Vitro Activity.

Clinical pharmacology and therapeutics - 1 Nov 2023

Zubiaur Pablo, Soria-Chacartegui Paula, Boone Erin C, Prasad Bhagwat, Dinh Jean, Wang Wendy Y, Zugbi Santiago, Rodríguez-Lopez Andrea, González-Iglesias Eva, Leeder J Steven, Abad-Santos Francisco, Gaedigk Andrea

Abstract excerpt

A novel haplotype composed of two non-coding variants, CYP2C18 NM_000772.3:c.*31T (rs2860840) and NM_000772.2:c.819+2182G (rs11188059), referred to as "CYP2C:TG," was recently associated with ultrarapid metabolism of various CYP2C19 substrates. As the underlying mechanism and clinical relevance of this effect remain uncertain, we analyzed existing in vivo and in vitro data to determine the magnitude of the...

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PMID: 37528442
DOI: 10.1002/cpt.3012
PMCID: PMC10592245

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