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Stem Cells and Exosomes: New Therapies for Intervertebral Disc Degeneration

29 Aug 2021

Abstract excerpt

Intervertebral disc degeneration (IVDD) occurs as a result of an imbalance of the anabolic and catabolic processes in the intervertebral disc, leading to an alteration in the composition of the extracellular matrix (ECM), loss of nucleus pulposus (NP) cells, excessive oxidative stress and inflammation. Degeneration of the IVD occurs naturally with age, but mechanical trauma, lifestyle factors and certain genetic...

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PMID: 34571890
DOI: 10.3390/cells10092241

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