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Article

Overlapping genetic etiology of pediatric and adult germ cell tumors.

Journal of the National Cancer Institute - 1 Sept 2026

Sullivan Shannon M, Lane John, Standafer Abigail, Mcfeeters James, Hubbard Aubrey K, Langer Erica K, Hooten Anthony J, Roesler Michelle A, Gell Joanna J, Krailo Mark, Frazier A Lindsay, Amatruda James F, Pankratz Nathan, Poynter Jenny N

Abstract excerpt

BACKGROUND: Germ cell tumors are heterogeneous neoplasms arising from primordial germ cells. Although genome-wide association studies have identified numerous susceptibility loci for adult testicular germ cell tumors, the heritable basis of pediatric testicular germ cell tumors and germ cell tumors that arise outside the testes remain poorly understood. METHODS: We conducted a multi-ancestry genome-wide...

Read the complete abstract on PubMed

Topics

Humans
Neoplasms, Germ Cell and Embryonal
Male
Genome-Wide Association Study
Testicular Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Child

Adolescent

Infant

Child, Preschool

Genetic Predisposition to Disease

Polymorphism, Single Nucleotide

Young Adult

Ovarian Neoplasms

Transcription Factors

Nerve Tissue Proteins

Brain Neoplasms

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 41941753
DOI: 10.1093/jnci/djag097
PMCID: PMC13422894

Genes

BAK1
DEPTOR
BGLAP
DMRT1
ITPR3
KIT
KITLG
LZTR1
MAD1L1
PLCL2
PMF1
SPRY4
TFAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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