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Article

Imaging genetics insights into the association between polymorphisms of HPA-axis genes and brain function alterations in depressed adolescents.

Journal of affective disorders - 1 Aug 2026

Tian Susu, Liang Qingqing, Zhou Wei, Hu Xinyi, Liu Yuxuan, Tian Jiayi, Luo Yunjiao, Fang Haiyan, Wang Wei

Abstract excerpt

OBJECTIVE: To investigate the interaction between HPA-axis gene polymorphisms (FKBP5, NR3C1, AVPR1B, SLC1A3, SKA2) and brain functional alterations in adolescent depression. METHODS: Between May 2021 and June 2024, 150 medication-naïve depressed adolescents and 44 healthy controls underwent HPA-axis SNP genotyping and resting-state fMRI scanning. Logistic regression was performed to evaluate SNP-depression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41935751
DOI: 10.1016/j.jad.2026.121733

Genes

SKA2
FKBP5
NR3C1
SLC1A3
AVPR1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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