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Article

Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults.

Journal of psychiatry & neuroscience : JPN - 1 Jan 2025

Chen Yu, Li Huey-Ting, Luo Xingguang, Li Guangfei, Ide Jaime S, Li Chiang-Shan R

Abstract excerpt

BACKGROUND: Genetic variants may confer risk for depression by modulating brain structure and function; evidence has underscored the key role of the subgenual anterior cingulate cortex (sgACC) in depression. We sought to examine how the resting-state functional connectivity (rsFC) of the sgACC was associated with polygenic risk for depression in a subclinical population. METHODS: Following published protocols, we...

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Identifiers

PMID: 39809531
DOI: 10.1503/jpn.240087
PMCID: PMC11737878

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