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Article

Mutation-specific dynamics of dedifferentiation trajectories and tumor-stromal interactions in thyroid cancer.

Molecular cancer - 16 Jul 2026

Joo Eun Hye, Song Young Shin, Lee Han Sai, Jung Gyeongseo, Chung Eun-Jae, Kim Su-Jin, Kim Yoo Hyung, Cho Sun Wook, Choi Hongyoon, Won Jae-Kyung, Park Woong-Yang, Park Young Joo

Abstract excerpt

Progression from differentiated thyroid cancer to anaplastic thyroid cancer (ATC) involves profound epithelial plasticity and remodeling of the tumor microenvironment (TME), but how BRAFV600E and RAS driver mutations shape these processes remains unclear. Here, we integrated single-nucleus RNA-seq, spatial transcriptomics, and bulk RNA-seq across BRAFV600E- and RAS-driven thyroid tumors to delineate...

Topics

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Cell Dedifferentiation
Epithelial-Mesenchymal Transition
Gene Expression Regulation, Neoplastic
Proto-Oncogene Proteins B-raf

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thyroid Carcinoma, Anaplastic

Thyroid Neoplasms

Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 42458477
DOI: 10.1186/s12943-026-02699-2
PMCID: PMC13374302

Genes

AREG
EGFR
PLAU
PLAUR
TNFRSF10B
TNFSF10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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