Leveraging the transcriptome-phenotype relationship to guide clinical management of papillary thyroid cancer.

Abstract excerpt

Background: Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy, with excellent survival but substantial variation in recurrence risk. Traditional clinicopathologic risk models, while still a cornerstone of current guidelines, overlook the biological differences between patients, resulting in both overtreatment and undertreatment. Content: Next-generation sequencing has advanced our...

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