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Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemia

20 Feb 2017

Abstract excerpt

BACKGROUND: The majority of individuals with acute myeloid leukemia (AML) respond to initial chemotherapy and achieve a complete remission, yet only a minority experience long-term survival because a large proportion of patients eventually relapse with therapy-resistant disease. Relapse therefore represents a central problem in the treatment of AML. Despite this, and in contrast to the extensive knowledge about...

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PMID: 28219393
DOI: 10.1186/s13045-017-0416-0

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