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Article

Metabolome-Wide Mendelian Randomization Assessing the Causal Relationship Between Blood Metabolites and Sarcopenia-Related Traits.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Apr 2024

Chen Simin, Dong Yiran, Aiheti Nuerbiyamu, Wang Jie, Yan Shikang, Kuribanjiang Kaidiriyan, Li Huilong, Peng Xing, Wupuer Abudunaibi, Li Yihan, Yang Lei, Zhao Jianping

Abstract excerpt

Sarcopenia is among the most common musculoskeletal illnesses, yet its underlying biochemical mechanisms remain incompletely understood. In this study, we used Mendelian randomization (MR) to investigate the causal relationship between the genetically determined blood metabolites and sarcopenia, with the overall objective of identifying likely molecular pathways for sarcopenia. We used 2-sample MR to investigate...

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PMID: 38366876
DOI: 10.1093/gerona/glae051

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