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Article

Sialic acid biophore directed design of enhanced affinity HN protein from Newcastle disease virus.

The FEBS journal - 1 Aug 2026

Neog Siddharth, Kumar Sachin, Nandy Satyendu, Trivedi Vishal

Abstract excerpt

The hemagglutinin-neuraminidase (HN) of Newcastle disease virus (NDV) is a multifunctional protein that mediates virus attachment to host sialic acid-containing receptors, exhibits neuraminidase activity, and promotes membrane fusion. Notably, purified HN protein also targets sialic acids on malaria-parasitised red blood cells (PRBCs), thereby reducing parasite viability, and is thus a potential therapeutic...

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Identifiers

PMID: 41931038
DOI: 10.1111/febs.70493
PMCID: PMC13489518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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