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Article

Sialic acid biophore directed design of enhanced affinity HN protein from Newcastle disease virus.

The FEBS journal - 1 Aug 2026

Neog Siddharth, Kumar Sachin, Nandy Satyendu, Trivedi Vishal

Abstract excerpt

The hemagglutinin-neuraminidase (HN) of Newcastle disease virus (NDV) is a multifunctional protein that mediates virus attachment to host sialic acid-containing receptors, exhibits neuraminidase activity, and promotes membrane fusion. Notably, purified HN protein also targets sialic acids on mala...

Topics

Newcastle disease virus
HN Protein
N-Acetylneuraminic Acid
Animals
Binding Sites
Humans
Protein Binding
Neuraminidase
Mutation
Erythrocytes

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41931038
DOI: 10.1111/febs.70493
PMCID: PMC13489518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-41931038-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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