Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk.

doi:10.1073/pnas.1111691108

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Article

Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk.

Proceedings of the National Academy of Sciences of the United States of America - 6 Sept 2011

Yuan Ping, Swanson Kurt A, Leser George P, Paterson Reay G, Lamb Robert A, Jardetzky Theodore S

Abstract excerpt

The paramyxovirus hemagglutinin-neuraminidase (HN) protein plays multiple roles in viral entry and egress, including binding to sialic acid receptors, activating the fusion (F) protein to activate membrane fusion and viral entry, and cleaving sialic acid from carbohydrate chains. HN is an oligome...

Topics

Crystallography, X-Ray
HN Protein
Mutation
Newcastle disease virus
Protein Multimerization
Protein Structure, Quaternary
Protein Structure, Secondary
Protein Structure, Tertiary

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Identifiers

PMID: 21873198
DOI: 10.1073/pnas.1111691108
PMCID: PMC3169104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-21873198-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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