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Article

Mechanisms of escape from the PGT128 family of anti-HIV broadly neutralizing antibodies.

Retrovirology - 2 Feb 2016

Krumm Stefanie A, Mohammed Hajer, Le Khoa M, Crispin Max, Wrin Terri, Poignard Pascal, Burton Dennis R, Doores Katie J

Abstract excerpt

BACKGROUND: Broadly neutralizing antibodies (bnAbs) directed against the mannose-patch on the HIV envelope glycoprotein gp120 have several features that make them desirable targets for vaccine design. The PGT125-131 bnAb family is of particular interest due to its superior breadth and potency. The overlapping epitopes recognized by this family are intricate and neutralization requires interaction with at least...

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Share to Antibodies, Neutralizing
Share to Epitopes, B-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HIV Envelope Protein gp120

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Source

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Identifiers

PMID: 26837192
DOI: 10.1186/s12977-016-0241-5
PMCID: PMC4736637

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