Article

The SjD Map: An interactive pathway tour into Sjögren’s disease signalling mechanisms

2025-09-13

Abstract excerpt

<h4>Objectives</h4> Sjögren’s disease (SjD) remains a major unmet medical challenge, marked by biological complexity, patient heterogeneity, and a lack of curative treatments. To advance the understanding of its pathogenesis and support therapeutic discovery, we developed a comprehensive knowledgebase in the form of a Molecular Interaction Map (MIM). <h4>Methods</h4> Differential expression analysis was performe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e56f09e2-34f0-5a05-943c-cb9dcda1d797
DOI: 10.1101/2025.09.08.674876

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The SjD Map: An interactive pathway tour into Sjögren’s disease signalling mechanismsDOI 10.1101/2025.09.08.674876Read

Genetic, Transcriptomic, and Epigenomic Insights into Sjögren's Disease: An Integrative Network Investigation and Immune Diseases Comparison.Semantic proximity Read

Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells.Semantic proximity Read

Defining the Role of Monocytes in Sjögren’s SyndromeSemantic proximity Read

Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 infection and primary Sjogren’s syndromeSemantic proximity Read

Deciphering the interferon gene signature spectrum: association with the clinical heterogeneity of Sjögren's disease.Semantic proximity Read

A Distinguishable Peripheral Blood and Conjunctival Transcriptome and Gut Microbiome in Sjögren's Disease: A Pilot StudySemantic proximity Read

Examining the biological pathways underlying clinical heterogeneity in Sjogren's syndrome: proteomic and network analysisSemantic proximity Read

Identifying Key Genes and Functionally Enriched Pathways in Sjögren’s Syndrome by Weighted Gene Co-Expression Network AnalysisSemantic proximity Read

A new molecular classification to drive precision treatment strategies in primary Sjögren's syndrome.Semantic proximity Read

BiomiX-Driven Multi-Omics Integration of PRECISESADS Data Reveals Lysophosphatidic Acid and Metabolic Pathway Signatures in B Cells and Immune Macroenvironment in Sjögren’s DiseaseSemantic proximity Read

Identification of novel genes associated with dysregulation of B cells in patients with primary Sjögren's syndromeSemantic proximity Read

Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren's syndromeSemantic proximity Read