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Regulation of Mitochondrial Oxidative Metabolism by Tumor Suppressor FLCN

13 Nov 2012

Abstract excerpt

BACKGROUND: Birt-Hogg-Dubé (BHD) syndrome is a hereditary hamartoma syndrome that predisposes patients to develop hair follicle tumors, lung cysts, and kidney cancer. Genetic studies of BHD patients have uncovered the causative gene, FLCN, but its function is incompletely understood. METHODS: Mice with conditional alleles of FLCN and/or peroxisome proliferator-activated receptor gamma coactivator 1-alpha...

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PMID: 23150719
DOI: 10.1093/jnci/djs418

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