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Article

Regulated recycling of mutant CFTR is partially restored by pharmacological treatment.

Journal of cell science - 15 Jun 2013

Holleran John P, Zeng Jianxin, Frizzell Raymond A, Watkins Simon C

Abstract excerpt

Efficient trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) to and from the cell surface is essential for maintaining channel density at the plasma membrane (PM) and ensuring proper physiological activity. The most common mutation, F508del, exhibits reduced surface expression and impaired function despite treatment with currently available pharmacological small molecules, called...

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Source

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Identifiers

PMID: 23572510
DOI: 10.1242/jcs.120196
PMCID: PMC3687701

Genes

CFTR
EHD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulated recycling of mutant CFTR is partially restored by pharmacological treatment.PMID 23572510Read ↗

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