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Tropism and Replication Competence of Cattle Influenza A(H5N1) Genotype B3.13 Virus in Human Bronchus and Lung Tissue.

Emerging infectious diseases - 1 May 2026

Hui Kenrie P Y, Ho John C W, Ng Ka-Chun, Webby Richard J, Peiris Malik, Nicholls John M, Chan Michael C W

Abstract excerpt

In 2024, influenza A(H5N1) genotype B3.13 viruses emerged from cattle and caused mild spillover infections in humans. Using human bronchus and lung tissue, we evaluated tropism, replication, and pathogenesis of 2 cattle influenza isolates. Those viruses showed moderate replication competence and induced robust proinflammatory responses, suggesting potential risk for human health.

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Identifiers

PMID: 41922194
DOI: 10.3201/eid3205.251926
PMCID: PMC13175097

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