Article
Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals.
Nature communications - 16 Jan 2026
Dholakia Vidhi, Quantrill Jessica L, Richardson Samuel A S, Pankaew Nunticha, Brown Maryn D, Yang Jiayun, Capelastegui Fernando, Masonou Tereza, Case Katie-Marie, Ajeian Jila, Woodall Maximillian N J, Magill Callum, Freimanis Graham, McCarron Amy, Staller Ecco, Sheppard Carol M, Brown Ian H, Murcia Pablo R, Smith Claire M, Iqbal Munir, Digard Paul, Barclay Wendy S, Pinto Rute M, Peacock Thomas P, Goldhill Daniel H
Abstract excerpt
In 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA resulting in spillbacks into poultry, wild birds and other mammals including humans. Here, we present molecular and virological evidence that the cattle B3.13 genotype H5N1 viruses rapidly accumulated adaptations in polymerase genes that enabled better replication in bovine cells and tissues, as...
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