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Cellular tropism of highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b viruses in human respiratory and bovine mammary epithelial cells.

Microbiology spectrum - 4 Aug 2026

Brock Nicole, Zeng Hui, Pappas Claudia, Kieran Troy J, Sun Xiangjie, Pulit-Penaloza Joanna A, Tumpey Terrence M, Maines Taronna R, Belser Jessica A

Abstract excerpt

The recent introduction and spread of HPAI A(H5N1) clade 2.3.4.4b viruses to U.S. dairy cattle demonstrate their ability to adapt to new mammalian hosts. Although multiple A(H5N1) genotypes have caused human infections, only two clade 2.3.4.4b genotypes (B3.13 and D1.1) have been detected in cattle, suggesting clade- or genotype-specific tropism. Understanding how these viruses replicate in human airway and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42466872
DOI: 10.1128/spectrum.01377-26
PMCID: PMC13436365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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