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Article

Electric Double Layer Phenomena Near Surfaces Irreversibly Trigger Assembly of Tau Protein.

Journal of the American Chemical Society - 15 Apr 2026

Masquelier Eloise, Hicks Madeline, Watkins Nicholas, Lim Norleakvisoth, Yi Justin, Morse Daniel E, Sepunaru Lior, Gordon Michael J

Abstract excerpt

The reversible folding and assembly of the human brain protein tau are regulated by charge neutralization through limited and reversible phosphorylation, enabling tau to bind tubulin and maintain the structural integrity of neuronal microtubules. However, in neurodegenerative diseases like Alzheimer's and related tauopathies, tau becomes hyperphosphorylated, detaches from tubulin, and irreversibly assembles into...

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PMID: 41921971
DOI: 10.1021/jacs.5c23171
PMCID: PMC13088244

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