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Article

Charge effects on the fibril-forming peptide KTVIIE: a two-dimensional replica exchange simulation study.

Biophysical journal - 18 Apr 2012

Jeon Joohyun, Shell M Scott

Abstract excerpt

The assembly of peptides into ordered nanostructures is increasingly recognized as both a bioengineering tool for generating new materials and a critical aspect of aggregation processes that underlie neurological diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. There is a major problem in understanding how extremely subtle sequence changes can lead to profound and often...

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PMID: 22768952
DOI: 10.1016/j.bpj.2012.03.019
PMCID: PMC3328716

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