Article
[Secretory phenotype of the human endothelial cells associated with replicative and induced aging.]
Advances in gerontology = Uspekhi gerontologii - 1 Jan 2022
Savitskiy D V, Linkova N S, Kvetnoy I M, Diatlova A S, Saraev G B, Kozlov K L, Paltseva E M
Abstract excerpt
The aging-associated secretory phenotype (SASP) is a heterogeneous phenotype of cells secreting pro-inflammatory cytokines, growth factors, apoptosis' regulatory molecules, and proteases. SASP is one of the three main hallmarks of senescent cells. Dysregulation of the synthesis of SASP-forming molecules leads to the development of age-associated diseases, including cardiovascular pathology. The aim of this study...
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