Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A comprehensive functional landscape of PRV replication and pathogenesis revealed by genome-wide transposon mutagenesis.

Veterinary microbiology - 1 May 2026

Yan Wanwan, Ruan Keyue, Chen Lingchao, Li Songnan, Liu Ting, Tong Wu, Gao Fei, Yu Lingxue, Kong Ning, Tong Guangzhi, Zheng Hao

Abstract excerpt

Pseudorabies virus (PRV) is a large double-stranded DNA alphaherpesvirus with a genome of approximately 145 kb containing nearly 70 genes. To systematically profile gene functions, we constructed a genome-wide mutant library by performing Tn5 transposon mutagenesis on the PRV infectious clone pBAC-JS2012. Through transposon sequencing, 277 BAC plasmids (pBAC-JS2012) containing a single-copy transposon insertion...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Transposable Elements
Share to Genome, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 1, Suid

Share to Mutagenesis

Share to Mutagenesis, Insertional

Share to Pseudorabies

Share to Virulence

Share to Virus Replication

Source

Identifiers

PMID: 41916128
DOI: 10.1016/j.vetmic.2026.111006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A comprehensive functional landscape of PRV replication and pathogenesis revealed by genome-wide transposon mutagenesis.PMID 41916128Read ↗

Construction and transposon mutagenesis in Escherichia coli of a full-length infectious clone of pseudorabies virus, an alphaherpesvirus.Semantic proximity Read ↗

Comparison of Pathogenicity-Related Genes in the Current Pseudorabies Virus Outbreak in ChinaSemantic proximity Read ↗

A comprehensive transposon mutant library of Francisella novicida, a bioweapon surrogate.Semantic proximity Read ↗

Evaluation of the impact of ul54 gene-deletion on the global transcription and DNA replication of pseudorabies virus.Semantic proximity Read ↗

Genetic analysis of cytomegalovirus by shuttle mutagenesis.Semantic proximity Read ↗

High-Resolution Functional Profiling of the Norovirus GenomeSemantic proximity Read ↗

Transposon Insertion Sequencing, a Global Measure of Gene Function.Semantic proximity Read ↗

Full-genome analysis and pathogenicity of a genetically distinct Russian PRRSV-1 Tyu16 strainSemantic proximity Read ↗

Systematic mapping of bacteriophage gene essentiality with HIDEN‑SEQSemantic proximity Read ↗

A Simplified Positive-Sense-RNA Virus Construction Approach That Enhances Analysis ThroughputSemantic proximity Read ↗

Transposomes: a system for identifying genes involved in bacterial pathogenesis.Semantic proximity Read ↗

Bacteriophage genome-wide transposon mutagenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.