Article
Noninvasive diagnosis and monitoring of mutations by deep sequencing of circulating tumor DNA in esophageal squamous cell carcinoma.
Biochemical and biophysical research communications - 18 Mar 2016
Luo Honglei, Li Hong, Hu Zhaoyang, Wu Hongjin, Liu Chenglin, Li Ying, Zhang Xiaoyan, Lin Ping, Hou Qiang, Ding Guohui, Wang Yan, Li Shuang, Wei Dongkai, Qiu Feng, Li Yixue, Wu Shixiu
Abstract excerpt
Circulating tumor DNA (ctDNA) is becoming an important biomarker in noninvasive diagnosis and monitoring of tumor dynamics. This study tested the feasibility of plasma ctDNA for the non-invasive analysis of tumor mutations in esophageal squamous cell carcinoma (ESCC) by sequencing of tumor, tumor-adjacent, and normal tissue, as well as pre-surgery and post-surgery plasma. Exome sequencing of eight patients...
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