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Article

Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes

26 May 2015

Abstract excerpt

Invading human leukocyte antigen-G+ (HLA-G+) extravillous trophoblasts (EVT) are rare cells that are believed to play a key role in the prevention of a maternal immune attack on foreign fetal tissues. Here highly purified HLA-G+ EVT and HLA-G- villous trophoblasts (VT) were isolated. Culture on fibronectin that EVT encounter on invading the uterus increased HLA-G, EGF-Receptor-2, and LIF-Receptor expression on...

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PMID: 26015573
DOI: 10.1073/pnas.1507977112

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