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Characterisation of Naturally Occurring MERS-CoV Spike Mutations and Their Impact on Fusion and Neutralisation.

Viruses - 18 Mar 2026

Dempsey Rachael, Goldswain Hannah, Newman Joseph, Thakur Nazia, MacGill Tracy, Myers Todd, Orr Robert, Bailey Dalan, Stewart James P, Aljabr Waleed, Hiscox Julian A

Abstract excerpt

In this study, the phenotypic consequences of naturally occurring single nucleotide polymorphisms (SNPs) in the Middle East respiratory syndrome coronavirus (MERS-CoV) Spike protein were investigated. The impact of Spike mutations on the syncytia formation and neutralisation of contemporary MERS-CoV strains is not currently well understood. Mutations were identified by aligning 584 MERS-CoV Spike sequences from...

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Identifiers

PMID: 41902285
DOI: 10.3390/v18030377
PMCID: PMC13030573

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