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Article

Genetic Regulation of Monocyte MicroRNAs and Their Implication in Musculoskeletal Diseases: A Cross-Ancestry Expression Quantitative Trait Loci and Imputation Study.

International journal of molecular sciences - 20 Mar 2026

Liu Yong, Su Kuan-Jui, Gong Yun, Tian Bo, Liu Anqi, Luo Zhe, Tian Qing, Qiu Chuan, Shen Hui, Xiao Hong-Mei, Deng Hong-Wen

Abstract excerpt

This study investigated the genetic regulation of microRNA (miRNA) expression in monocytes and its potential role in musculoskeletal diseases. We mapped expression quantitative trait loci (eQTLs) for miRNAs using data from 281 Caucasian (CAU) and 170 African American (AA) individuals, constructed ancestry-specific models to impute miRNA expression from genotype data, and applied these models to test associations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41898677
DOI: 10.3390/ijms27062818
PMCID: PMC13026450

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