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Article

Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression.

PloS one - 1 Jan 2012

Greliche Nicolas, Zeller Tanja, Wild Philipp S, Rotival Maxime, Schillert Arne, Ziegler Andreas, Deloukas Panos, Erdmann Jeanette, Hengstenberg Christian, Ouwehand Willem H, Samani Nilesh J, Schunkert Heribert, Munzel Thomas, Lackner Karl J, Cambien François, Goodall Alison H, Tiret Laurence, Blankenberg Stefan, Trégouët David-Alexandre

Abstract excerpt

We aimed to assess whether pri-miRNA SNPs (miSNPs) could influence monocyte gene expression, either through marginal association or by interacting with polymorphisms located in 3'UTR regions (3utrSNPs). We then conducted a genome-wide search for marginal miSNPs effects and pairwise miSNPs × 3utrSNPs interactions in a sample of 1,467 individuals for which genome-wide monocyte expression and genotype data were...

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Source

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Identifiers

PMID: 23029284
DOI: 10.1371/journal.pone.0045863
PMCID: PMC3448685

Genes

CNTN6
COPZ2
CTRC
KRT9
LRRFIP1
LYZ
NOD1
PCDHA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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