Article
Acquisition of clofazimine resistance following bedaquiline treatment for multidrug-resistant tuberculosis.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Jan 2021
Liu Yuhong, Gao Jingtao, Du Jian, Shu Wei, Wang Lu, Wang Yufeng, Xue Zhongtan, Li Liang, Xu Shaofa, Pang Yu
Abstract excerpt
OBJECTIVES: We described the prevalence of clofazimine (CFZ) resistance in a multidrug-resistant tuberculosis (MDR-TB) cohort in China. We also aimed to identify dynamic changes in CFZ susceptibility and its molecular mechanism after exposure to bedaquiline (BDQ) and/or CFZ. METHODS: The experimental settings were conducted based on our MDR-TB cohort receiving BDQ-containing regimens. Sequential isolates were...
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