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Detection of single nucleotide variants in nucleic acid biomarkers using Raman spectroscopy.

Biosensors & bioelectronics - 15 Jul 2026

Holomb Roman, van Nguyen Huy, Allabush Francia, Quy Alex S, Sik Attila, Müller Ferenc, Himics László, Váczi Tamás, Tucker James H R, Veres Miklós, Fossey John S

Abstract excerpt

Single nucleotide variants (SNVs), including single-nucleotide polymorphisms, are key biomarkers for numerous human diseases, including cancer, and their accurate detection at single loci remains a major diagnostic challenge. Imaging-based approaches for in situ nucleic acid analysis further require highly specific, non-fluorescent readout strategies. Here, we report a Raman spectroscopy-based method for...

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Alkynes
Biosensing Techniques
DNA
BRAF gene
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins B-raf

Spectrum Analysis, Raman

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PMID: 41895233
DOI: 10.1016/j.bios.2026.118574

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BRAF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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