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Shining Light on DNA Mutations through Machine Learning-Augmented Vibrational Spectroscopy.

Analytical chemistry - 17 Jun 2025

Yadav Vikas, Ahuja Tripti, Kharbanda Himanshi, Kumar Dinesh, Siddhanta Soumik

Abstract excerpt

A method to directly predict the number of nucleic acid bases in a single-stranded DNA (ssDNA) or a genomic DNA has been proposed with a combination of Raman spectroscopy and an Artificial Neural Network (ANN) algorithm. In this work, the algorithm was trained by using the Raman spectroscopic signatures from a cohort of 32 ssDNAs. The algorithm could predict the number of bases in an unknown sequence with an R2...

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PMID: 40462527
DOI: 10.1021/acs.analchem.5c00183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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