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C5-functionalized DNA, LNA, and α-L-LNA: positional control of polarity-sensitive fluorophores leads to improved SNP-typing.

Chemistry (Weinheim an der Bergstrasse, Germany) - 7 Mar 2011

Østergaard Michael E, Kumar Pawan, Baral Bharat, Guenther Dale C, Anderson Brooke A, Ytreberg F Marty, Deobald Lee, Paszczynski Andrzej J, Sharma Pawan K, Hrdlicka Patrick J

Abstract excerpt

Single nucleotide polymorphisms (SNPs) are important markers in disease genetics and pharmacogenomic studies. Oligodeoxyribonucleotides (ONs) modified with 5-[3-(1-pyrenecarboxamido)propynyl]-2'-deoxyuridine monomer X enable detection of SNPs at non-stringent conditions due to differential fluorescence emission of matched versus mismatched nucleic acid duplexes. Herein, the thermal denaturation and optical...

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PMID: 21328492
DOI: 10.1002/chem.201002109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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