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Demonstration of a Superior Deep-UV Surface-Enhanced Resonance Raman Scattering (SERRS) Substrate and Single-Base Mutation Detection in Oligonucleotides.

Journal of the American Chemical Society - 24 Nov 2021

Dubey Abhishek, Mishra Ragini, Cheng Chang-Wei, Kuang Yu-Ping, Gwo Shangjr, Yen Ta-Jen

Abstract excerpt

In life science, rapid mutation detection in oligonucleotides is in a great demand for genomic and medical screening. To satisfy this demand, surface-enhanced resonance Raman spectroscopy (SERRS) in the deep-UV (DUV) regime offers a promising solution due to its merits of label-free nature, strong electromagnetic confinement, and charge transfer effect. Here, we demonstrate an epitaxial aluminum (Al) DUV-SERRS...

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PMID: 34748330
DOI: 10.1021/jacs.1c09762

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