Article
Bi-directional association between RUNX1::RUNX1T1 and KIT mutations in acute myeloid leukemia: A multicenter genomic profiling study.
Leukemia research - 1 May 2026
Arai Yuya, Katagiri Seiichiro, Chi SungGi, Yoshimoto Goichi, Yamauchi Takahiro, Kobayashi Takahiro, Nakamura Yukinori, Ishitsuka Kenji, Fukushima Kentaro, Minami Yosuke, Gotoh Akihiko, Akahane Daigo
Abstract excerpt
Next-generation sequencing has delineated recurrent genomic lesions in acute myeloid leukemia (AML), with mutations in some genes exhibiting prognostic relevance. Studies have reported that KIT mutations may confer an adverse risk in AML with RUNX1::RUNX1T1. However, in real-world practice, the bi-directional relationship between RUNX1::RUNX1T1 and KIT mutations and the impact on outcome remains insufficiently...
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