Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrative Multi-Omics Analysis Uncovers Immunological Phenotypes Predictive of Combinatorial Immunotherapy Response in Gastric Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Jan 2026

Wang Jianchao, Zhang Wenfang, Zhang Jiyang, Zhao Chenhui, Zhang Wei, Fang Menghan, Chen Fangfang, Wu Zhida, Xu Xiaoya, Yu Ziqing, Zhu Qiong, Shi Yi, Zhang Dadong, Chen Xiaofeng, Chen Gang

Abstract excerpt

Current understanding of immune characteristics in gastric cancer remains limited for guiding clinical practice, particularly immunotherapy. This study aims to elucidate the multidimensional landscape of tumor microenvironment in gastric cancer, identify predictive biomarkers potentially associated with favorable immunotherapy response, and propose a precision stratification framework to inform therapeutic...

Topics

Join the communities discussing this publication.

Biomarkers, Tumor
Immunotherapy
Multiomics
Phenotype
Stomach Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 41229377
DOI: 10.1002/advs.202514482
PMCID: PMC12866680

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrative Multi-Omics Analysis Uncovers Immunological Phenotypes Predictive of Combinatorial Immunotherapy Response in Gastric Cancer.PMID 41229377Read ↗

Gastric Cancer Tumor Immune Microenvironment Landscape: Clinical Implications for Patient Outcome and Response to PD-1 Immune Checkpoint BlockadeSemantic proximity Read ↗

Comprehensive immunophenotyping of gastric adenocarcinoma identifies an inflamed class of tumors amenable to immunotherapiesSemantic proximity Read ↗

Immunogenomic characterization in gastric cancer identifies microenvironmental and immunotherapeutically relevant gene signatures.Semantic proximity Read ↗

Comprehensive dissection of immune microenvironment in the progression of early gastric cancer at spatial and single-cell resolutionSemantic proximity Read ↗

Immune cell infiltration signatures identified molecular subtypes and underlying mechanisms in gastric cancerSemantic proximity Read ↗

Mapping spatial heterogeneity in gastric cancer microenvironment.Semantic proximity Read ↗

Single-cell RNA sequencing revealed heterogeneity of the immune microenvironment in gastric cancerSemantic proximity Read ↗

Immune Microenvironment Spatial Landscapes of Tertiary Lymphoid Structures in Gastric CancerSemantic proximity Read ↗

Identifying immune cells-related phenotype to predict immunotherapy and clinical outcome in gastric cancer.Semantic proximity Read ↗

High-Dimensional Spectral Cytometry Reveals Therapeutically Relevant Immune Subtypes in Gastric CancerSemantic proximity Read ↗

A Stromal-Immune Gene Signature for Precision Prognosis and Therapeutic Guidance in Gastric CancerSemantic proximity Read ↗

Pyroptosis Patterns Characterized by Distinct Tumor Microenvironment Infiltration Landscapes in Gastric CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.