Article
Identification of critical genetic variants associated with metabolic phenotypes of the Japanese population.
Communications biology - 11 Nov 2020
Koshiba Seizo, Motoike Ikuko N, Saigusa Daisuke, Inoue Jin, Aoki Yuichi, Tadaka Shu, Shirota Matsuyuki, Katsuoka Fumiki, Tamiya Gen, Minegishi Naoko, Fuse Nobuo, Kinoshita Kengo, Yamamoto Masayuki
Abstract excerpt
We performed a metabolome genome-wide association study for the Japanese population in the prospective cohort study of Tohoku Medical Megabank. By combining whole-genome sequencing and nontarget metabolome analyses, we identified a large number of novel associations between genetic variants and plasma metabolites. Of the identified metabolite-associated genes, approximately half have already been shown to be...
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