Article
Gut microbiome associations with host genotype vary across ethnicities and potentially influence cardiometabolic traits.
Cell host & microbe - 12 Oct 2022
Boulund Ulrika, Bastos Diogo M, Ferwerda Bart, van den Born Bert-Jan, Pinto-Sietsma Sara-Joan, Galenkamp Henrike, Levin Evgeni, Groen Albert K, Zwinderman Aeilko H, Nieuwdorp Max
Abstract excerpt
Previous studies in mainly European populations have reported that the gut microbiome composition is associated with the human genome. However, the genotype-microbiome interaction in different ethnicities is largely unknown. We performed a large fecal microbiome genome-wide association study of a single multiethnic cohort, the Healthy Life in an Urban Setting (HELIUS) cohort (N = 4,117). Mendelian randomization...
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